Effects of Hypertonic (10%) Saline in Patients With Raised Intracranial Pressure After Stroke

Effects of hypertonic (10%) saline in patients with raised intracranial pressure after stroke.

BACKGROUND AND PURPOSE The aim of this study was to evaluate the effects of hypertonic saline in stroke patients with increased intracranial pressure (ICP) after conventional therapy with mannitol had failed. METHODS Twenty-two episodes of ICP crisis occurred in 8 patients in whom the standard treatment of 200 mL of 20% mannitol was not effective. ICP crisis was defined as an increase in ICP ...

Effects of hypertonic saline hydroxyethyl starch solution and mannitol in patients with increased intracranial pressure after stroke.

BACKGROUND AND PURPOSE The purpose of this study was to prospectively evaluate a protocol with hypertonic saline hydroxyethyl starch (HS-HES) and mannitol in stroke patients with increased intracranial pressure (ICP). METHODS We studied 30 episodes of ICP crisis in 9 patients. ICP crisis was defined as (1) a rise of ICP of more than 25 mm Hg (n = 22), or (2) pupillary abnormality (n=3), or (3...

Hypertonic saline for treating raised intracranial pressure: literature review with meta-analysis.

OBJECT Currently, mannitol is the recommended first choice for a hyperosmolar agent for use in patients with elevated intracranial pressure (ICP). Some authors have argued that hypertonic saline (HTS) might be a more effective agent; however, there is no consensus as to appropriate indications for use, the best concentration, and the best method of delivery. To answer these questions better, th...

Hypertonic saline for treating raised intracranial pressure: literature review with meta-analysis A review

210 J Neurosurg / Volume 116 / January 2012 INTRACRANIAL hypertension following neurological injury is often associated with poor outcomes.13 Increased ICP reduces CBF and can lead to brain herniation and death. The Brain Trauma Foundation has recommended that therapy to reduce ICP should begin at pressures > 20 mm Hg. Hyperosmolar therapy is a commonly used treatment for intracranial hypertens...

Effects of hypertonic saline on intracranial pressure variables in subarachnoid haemorrhage patients